The Langenau laboratory research focus is to uncover the mechanisms that drive relapse in pediatric tumors with the long term goal of identifying novel therapeutic drug targets for treatment of relapse disease. Using novel zebrafish models of pediatric sarcoma and leukemia that mimic human malignancy, we have undertaken studies to discover novel therapies by addition of drugs to the water and imaging tumor growth in live zebrafish. Moreover, we have utilized detailed imaging studies to visualize tumor cells in live animals and assess how cellular heterogeneity drives continued tumor growth. Capitalizing on insights gained from our zebrafish models of cancer, we are now extending our findings to human T-cell acute lymphoblastic leukemia and rhabdomyosarcoma.
Contact: David Langenau
Address: 149 13th St., #6012, Charlestown MA 02129