Cell transplantation of human and mouse cells into immune compromised mice and greatly impacted our understanding of stem cell function, regeneration following injury, and cancer. However, these transplantation experiments routinely utilize small cohorts of mice due to high husbandry costs and engraftment of cells is difficult to visualize, especially at single cell resolution. Capitalizing on transparent zebrafish and genome engineering approaches, we are developing mutant zebrafish lines that have impaired immune cell function resulting from similar mutations as observed in commonly utilized immunocompromised mouse strains and mimic mutations found in human severe combined immunodeficiency (SCID). These immune compromised zebrafish lines will be useful for adoptive transfer of zebrafish, mouse, and human cells. This work is supported by an R24 Resource Grant from the Office of the Director at NIH (R24OD016761).

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